Cisplatin in animal bedding

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August undefined, 2024

WebCisplatin is an antitumor drug used in the treatment of a wide variety of malignancies. However, its primary dose-limiting side effect is kidney injury, which is a major clinical concern. To help understand mechanisms … WebIt is not at all surprising that cisplatin retards tumor growth in our animal model. Cisplatin is an alkylating agent that is cell cycle nonspecific, and has long been used in the management of breast cancer . Relative to a single bolus at time 0, multidosing regimens show some advantage (Figure 2). One might infer that, at least in the case of ...

STANDARD OPERATING PROCEDURE #715 USE OF CISPLATIN IN …

WebMay 15, 2024 · The doses of cisplatin were applied based initially on those described in mouse models 15, 16, 17, in which the standard used is 10-13 mg of cisplatin per kg of animal (mg/kg). However, the zebrafish showed to be more resistant to cisplatin than the mouse (data not shown), and the final dose was increased. WebOct 7, 2024 · Cisplatin causes acute and chronic effects in the gastrointestinal tract. A single injection of cisplatin causes pica, a rodent-specific behavior of nausea, which reflects as a progressive reduction in food intake, increase in non-nutritive material intake (for instance bedding) and decreased gastric motility . northland irrigation mn

Complex comprised of dextran magnetite and conjugated cisplatin ...

WebAnimal bedding is not to be changed for at least 3 days after the date of the last administration of Cisplatin Disposable gown and a 2nd pair of gloves in addition to the … WebApr 17, 2024 · Animals. Animal preparation All protocols were approved by the Institutional Animal Care and Use Committee and conducted accordingly to the Guide for the Care and Use of Laboratory Animals … WebMay 1, 2005 · The antineoplastic drug cisplatin, whose use in humans is limited by kidney toxicity, also causes typical histological changes and a decline in renal function in larval zebrafish. A specific inhibitor of Omi/HtrA2, a serine protease implicated in cisplatin-induced apoptosis, prevented renal failure and increased survival. northland irrigation wisconsin

Cisplatin Mouse Models: Treatment, Toxicity and Translatability

The potent melanocortin receptor agonist melanotan-II …

Web2. Animal cages and bedding are considered hazardous for a minimum of 3 days (36 hours) after an injection. The first cage change after each drug administration is to be done no sooner than 3 days after the administration. 3. The bedding is considered contaminated and requires special handling. The first bedding change WebAccordingly, in the present studies, we sought to determine (i) the effects of cisplatin treatment on thermal and mechanical thresholds, (ii) the effects of this treatment on DRG … northland ispWebFeb 21, 2003 · In short, cisplatin was administered twice a week at a dose of 2 mg kg −1 by intraperitoneal injection. Routinely, rats thus treated develop a sensory neuropathy after 2–3 weeks, as evidenced by slowing of the sensory nerve conduction velocity. northland investments utah

"WebJan 12, 2024 · Administration of cilastatin suppressed cisplatin-induced kidney injury. (A) BALB/cA mice were administered cisplatin i.p. at a dose of 3 mg/kg or 6 mg/kg on days 0, 3 and 6.Mice that received 6 ... " - Cisplatin in animal bedding

Cisplatin in animal bedding

The use of cisplatin-loaded mucoadhesive nanofibers for local ...

WebMar 15, 2024 · Cisplatin, a heavy metal complex, is one of the most effective chemotherapeutic agents used for the treatment of a wide variety of malignancies (Zhang and Lippard, 2003). However, dose-dependent and cumulative nephrotoxicity is a major side effect of cisplatin, leading to reduction in dosage or ceasing its use. WebJul 12, 2024 · Cisplatin is used to treat a number of different tumors in dogs. The most common ones include osteosarcoma, squamous cell carcinoma, bladder tumors, ovarian …

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WebAbstract Cisplatin is a highly emetogenic cancer chemotherapy agent, which is often used to induce nausea and emesis in animal models. The cytotoxic properties of cisplatin … Webwoodchip bedding under a 12 : 12 h light : dark cycle and room temperature 22–24ºC. Rats were acclimatized to the ... In the Cisplatin-treated group, animals were given a single intraperitoneal dose of Cisplatin (10 mg/kg body weight), used previously to induce testicular toxicity in various animal species (9, 41); Following diethyl ether ...

WebJan 12, 2024 · To evaluate whether cilastatin influences the antitumor effects of cisplatin in human cancer cells, SCID mice were injected with A549 human lung adenocarcinoma … WebCisplatin, a single dose of 3.5 mg/kg, i.p., was injected on day 1 which served as standard drug. Every third day animals were weighed to assess the tumor growth. The animals were monitored daily for 45 days and mortality was recorded to calculate the MST (mean survival time). The percentage increase in life span (ILS) was calculated by the ...

WebOct 5, 2014 · Cisplatin, cisplatinum, or cis-diamminedichloroplatinum (II), is a well-known chemotherapeutic drug. It has been used for treatment of numerous human cancers including bladder, head and neck, lung, ovarian, and testicular cancers. It is effective against various types of cancers, including carcinoma … WebFresh micro-isolator caging will be used for the animals at the time of administration. Danger Sign . must be posted on the door of the room in which the animals will be …

WebJun 1, 2015 · To study the bio-distribution of Flu or cisplatin released from the fiber-mat implanted in the mice vagina, fluorescence imaging or ICP-MS were used to detect Flu …

WebOct 7, 2024 · The severity of mucosal damage along the gastrointestinal tract is dose-dependent [72]. Mucosal damage with inflammation, digestive dysfunction, disruption of … northland isiteWebOct 7, 2024 · Despite guidelines to navigate management of gastrointestinal side effects, diarrhea is responsible for about 5% of early deaths during chemotherapy [ 110 ]. … northland iolaWebApr 8, 2024 · First, we did not include additional animal groups, e.g., normal mice, MNU and INS-GAS mice that should be treated with PEITC or cisplatin alone and combination of PEITC plus cisplatin to explore the possibilities that PEITC may have differential effects on gastric cancer cells compared to normal gastric epithelial cells and that there is ... how to say sacramentoWebOct 7, 2024 · Cisplatin retention in the tissues can be evaluated also by detecting cisplatin-DNA adducts, a method usually used in the nervous system (see section neurotoxicity). northland isd 118WebAug 9, 2010 · Abstract and Figures We developed a dextran-magnetite conjugated cisplatin (DM-Cis) complex for use in thermal ablation and as a chemotherapeutic drug. To produce DM-Cis we reacted Cis with 1 mL... northland island mapWebOct 7, 2024 · Cisplatin is one of the most widely used chemotherapeutic drugs in the treatment of a wide range of pediatric and adult malignances. However, it has various … northland isuzuWebDec 5, 2007 · Beads are 3 mm in diameter and contain ≈1.6 mg of cisplatin/bead [c]. Beads are sterilized by means of gamma irradiation and stored in the dark at room temperature … northland isanti mn