WebFeb 7, 2012 · Liver fibrosis is a major cause of liver failure, but treatment remains ineffective. In the present study, we investigated the mechanisms and anti-hepatofibrotic activities of asiatic acid (AA) in a rat model of liver fibrosis induced by carbon tetrachloride (CCl4) and in vitro in TGF-beta1-stimulated rat hepatic stellate cell line (HSC-T6). … WebOct 4, 2012 · The pro-fibrogenic cytokine connective tissue growth factor (CTGF) plays an important role in the development and progression of fibrosis in many organ systems, …
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WebMay 10, 2024 · Adiponectin-deficient mice develop enhanced liver fibrosis with increased hepatic expression of TGFβ and CTGF after CCl 4 administration, whereas viral overexpression of adiponectin prevents and ... WebOct 3, 2024 · Organ fibrosis often ends in eventual organ failure and leads to high mortality. Although researchers have identified many effector cells and molecular pathways, there are few effective therapies for fibrosis to date and the underlying mechanism needs to be examined and defined further. Epoxyeicosatrienoic acids (EETs) are endogenous lipid …
WebJun 13, 2024 · Connective tissue growth factor (CTGF, also known as CCN2), a member of the CCN family of matricellular proteins, is widely known as a hallmark of fibrosis in multiple tissues, including skin, heart, lung, liver, and kidney [ 3, 4 ]. WebMay 2, 2006 · Connective tissue growth factor (CTGF) is a highly profibrogenic molecule implicated in hepatic fibrogenesis. Small interfering RNA (siRNA) is an effective tool to …
WebMar 20, 2024 · Liver fibrosis (LF) is caused by chronic liver injury from various causes, such as viral infections, alcohol consumption, non-alcoholic fatty liver disease (NAFLD), cholestatic liver disease, and autoimmune hepatitis. ... resulting in the inhibition of CTGF and its downstream targets . WebApr 8, 2024 · Multiple studies illustrate the abilities of neutralizing anti-TGF-β antibodies and TGF-β receptor kinase inhibitors to prevent fibrosis in preclinical models of lung, liver, …
WebNov 5, 2024 · Liver fibrosis is end-stage liver disease that can be rescued. If irritation continues due to viral infection, schistosomiasis and alcoholism, liver fibrosis can progress to liver cirrhosis and even cancer. ... CTGF, p16, CCL2 and SA-β-gal, ultimately leading to a profibrogenic micro-environment, HSC activation, and enhanced liver fibrosis ...
WebHepatic fibrosis, which has characteristics of excessive deposition of extra cellular matrix (ECM), occurs by various chronic liver injuries, such as from chemicals, viral infection, and alcoholic or nonalcoholic hepatic steatosis [].Although the pathogenesis of hepatic fibrosis is not revealed clearly, hepatic stellate cells (HSCs) are believed to be a major role in the … dallas hardware screws for tac knivesWebOct 3, 2024 · Organ fibrosis often ends in eventual organ failure and leads to high mortality. Although researchers have identified many effector cells and molecular pathways, there … dallas halloweenWebAug 1, 2024 · The secretory character of CTGF and its production by various cell types in liver disease makes it a potential biomarker for the diagnosis of liver fibrosis and its progression. Several clinical studies have demonstrated significantly increased serum or plasma CTGF in patients with fibrotic/cirrhotic liver disease. dallas hall of stateWebDec 12, 2024 · TGF-β1, platelet-derived growth factor (PDGF), connective tissue growth factor (CTGF), TNF-α, and vascular endothelial growth factor (VEGF) are all involved in key mechanisms of fibrosis. 9,14 TGF-αis particularly important in mediating stellate cell activation to myofibroblasts and stellate cell collagen production. 14 VEGF and PDGF … birch lane school davisWebJun 1, 2009 · CTGF participates in cell proliferation, migration, and differentiation and mediates profibrotic activity by acting either directly, or as a co-factor for TGF beta 1, … birch lane round metal coffee tableWebJun 5, 2024 · Therefore, NNMT, in conjunction with a NAM-rich diet, aggravates liver fibrosis, at least in part, through epigenetic changes to CTGF. Body weight and adiposity decreased in Tg mice fed an HFD ... birch lane sign inWebMay 8, 2024 · Connective tissue growth factor (CTGF) associated with transforming growth factor-β (TGF-β) play a pivotal role in the pathophysiology of many fibrotic disorders. … dallas hard eight bbq