Web6 de out. de 2024 · Hypoxia-inducible factor 1α (HIF-1α) and HIF-2α are master transcription factors that regulate cellular responses to hypoxia, but the exact function in regulatory T (Treg) cells is controversial. Here, we show that Treg cell development is normal in mice … WebHypoxia-inducible factor (HIF) is essential for the cellular response to hypoxia (1,2). Under normoxia conditions, the α subunit of HIF is ubiquitinated by von Hippel-Lindau (VHL) protein and is degraded in the ubiquitin/proteasome pathway (1,2). Hypoxia inhibits degradation of the α subunit, which leads to its stabilization (1,2).
EPAS1 gene: MedlinePlus Genetics
WebNational Center for Biotechnology Information WebEPAS1. Endothelial PAS domain-containing protein 1 ( EPAS1, also known as hypoxia-inducible factor-2alpha (HIF-2α)) is a protein that is encoded by the EPAS1 gene in mammals. It is a type of hypoxia-inducible factor, a group of transcription factors involved in the physiological response to oxygen concentration. birth celebration
FDA Grants Breakthrough Therapy Designation to Merck’s Novel …
Web12 de fev. de 2024 · Chronic hypoxia is related to the pathogenesis of NASH. HIF-2α is the key gene for lipid metabolism, fibrosis, and inflammation in many cells. To identify the molecular mechanism through which hypoxia exposure increases the morbidity of NASH, the expression level of HIF-2α was analysed and was found to be upregulated in human … Web1 de mar. de 2024 · In this study, we generated zebrafish mutants for hif-2α (hif-2aa;hif-2ab), which exhibit a reduction in ECs undergoing EHT, and show that hif-1α and hif-2α both play a role in this process. Exposure to hypoxia strongly induces EHT in wild-type (WT) embryos and partially rescues the phenotype in hif-1α and hif-2α single mutants. Web6 de out. de 2024 · CD4+ T cells deficient in both HIF-1α and HIF-2α revealed a substantial role for HIF-2α in this process, in particular in Ag-specific IgM expression and in boosting hapten-carrier immunization. HIF-1α is also required for the expression of the CD40 ligand on follicular T helper cells, which interact with the CD40 on B cells promoting proliferation … birth celebration invitation card