WebHiguchi et. al, "Phase-Solubility Technique in Studying the Formation of Complex Salts of Triamterene,", 1964. Higuchi and Connors, "Phase-Solubility Techniques,", 1964. Higuchi … WebHiguchi, T., Connors, K.A., Phase-solubility techniques, Adv. Anal. Inst., 4, 117–212 (1965) Google Scholar Higuchi, T., Kristiansen, H., J ., Binding specificity between small organic solutes in aqueous solution: Classification of some solutes into two groups according to binding tendencies, Pharm. Sci., 59, 1601–1608 (1970) Google Scholar
Enhancement of aqueous solubility of tricyclic acyclovir ... - Springer
WebThe shake-flask method is based on the phase solubility technique that was developed 40 years ago and is still the most reliable and widely used method for solubility measurement today (Higuchi and Connors, 1965). The method can be divided into hve steps sample preparation, equilibration, separation of phases, analysis of the saturated solution ... WebThe Higuchi–Connors phase diagram indicated the formation of weak 1:1 and 1:2 complexes. In addition, the reaction conditions were applied to poly (vinylimidazole) and 1,4-bis (1 H -imidazol-1-yl)butane to obtain functionalized polymer networks and oligomers, which were stable at temperatures up to 300 °C and 200 °C, respectively. Experimental razorpay flutter
(Open Access) Phase solubility techniques (1965) T K Higuchi
WebIn vitro transdermal permeation behavior of isosorbide dinitrate in the absence and presence of 2-hydroxypropyl-β-cyclodextrin: solutions and suspensions. Interactions of a … WebThe Higuchi窶鼎onnors phase-solubility method8)is very often used to determine K 1:1 , as a part of a formulation study. This method is based on the effect of a complex forming lig- and, e.g.CD, on the solubility of the drug. The intrinsic solu- bility (S 0 ) and the slope of the phase-solubility diagram are then used to calculate K 1:1 WebThe study of phase solubility was based on the Higuchi & Connors method and showed an impressive enhancement of the miscibility of furosemide with water. In fact, a 11 fold increase of the drug solubility was recorded for the inclusion complex, in the first stages of dissolution. The experimental results of this work show that 2-Hydroxypropyl ... razorpay extension